Fig. 1

CRNDE expression in tissues and cells of glioma and the clinicopathological characteristics and prognosis of patients with glioma. a CRNDE expression in normal brain tissues and glioma tissues was determined by qRT-PCR. ^***P < 0.001. b CRNDE expression was measured in normal brain tissues and glioma tissues at different pathological stage by qRT-PCR. ^*P < 0.05, ^***P < 0.001. c CRNDE expression was detected in glioma tissues showing response (R +) or no response (R-) to TMZ in high-grade tumors versus normal tissues. ^**P < 0.01, ^***P < 0.001. d Kaplan–Meier plot of overall survival of patients was stratified by CRNDE expression. e CRNDE expression was determined by qRT-PCR in three glioma cell lines (U251, U87 and PGC) versus a normal cell line (HNA). ^**P < 0.01, ^***P < 0.001. Data are presented as mean ± SD from three independent experiments