Fig. 3

Knockdown CRNDE suppressed the TMZ-induced autophagy in glioma cells. a Western blot revealed the rate of protein LC3 II/I, protein levels of Beclin 1 and p62 in autophagic flux after treated with TMZ at 100 μM for 72 h in U87 and PGC lines. ^*P < 0.05, ^**P < 0.01. b Western blot showed the rate of protein LC3 II/I, protein levels of Beclin 1, Atg5 and p62 after CRNDE knockdown with the same treatment in U87 and PGC lines. ^*P < 0.05, ^**P < 0.01. Data are presented as mean ± SD from three independent experiments