Fig. 5

Knockdown CRNDE enhanced sensitivity to TMZ and reduced ABCG2 expression in vivo. a Representative images of xenograft tumors produced by CRNDE silenced or control cells in nude mice with TMZ treatment. b Tumor growth volume curve of the CRNDE knockdown subcutaneous PGC xenografts. ^*P < 0.05, ^**P < 0.01. c Tumor growth weights of the CRNDE knockdown subcutaneous PGC xenografts. ^**P < 0.01. d Representative IHC images of ABCG2 expression in subcutaneous xenograft tumor tissue. Original magnification ×100 (Scale bars = 100 μΜ), X200 (Scale bars = 50 μΜ) and X400 (Scale bars = 25 μΜ). e The analysis of total gray value. ^**P < 0.01. Data are presented as mean ± SD from three independent experiments. ^**P < 0.01