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Table 4 Relationships between different checkpoints

From: Lymphocyte activating gene 3 protein expression in nasopharyngeal carcinoma is correlated with programmed cell death-1 and programmed cell death ligand-1, tumor-infiltrating lymphocytes

Characteristics

LAG-3 expression on TILs

High (> 14)

Low (≤ 14)

p value

PD-1 expression on TILs, n (%)

 High (> 2)

79 (43.4)

11 (6.0)

0.018

 Low (≤ 2)

68 (37.4)

24 (13.2)

(1.157–5.5)

PD-L1 expression on TC, n (%)

 High (> 9)

25 (13.7)

14 (7.7)

0.003

 Low (≤ 9)

122 (67)

21 (11.6)

 

PD-L1 expression on TILs, n (%)

 High (> 1%)

130 (71.4)

24 (13.2)

0.003

 Low (≤ 1%)

17 (8.9)

11 (6.5)

 

CD3+ TIL, n (%)

 High (> 215)

105 (57.7)

20 (11)

0.101

 Low (≤ 215)

42 (23.1)

15 (8.2)

 

GZMB, n (%)

 High (> 112)

39 (21.4)

5 (3.3)

0.128

 Low (≤ 112)

108 (58.8)

30 (16.5)

 
  1. All the p values marked in bold are less than 0.05, which is statistically significant
  2. LAG-3: lymphocyte activating 3; CI: confidence interval; PD-L1: programmed death ligand 1; PD-1: programmed death 1; TIL: tumor-infiltrating lymphocyte; TC: tumor cell; GZMB: granzyme B
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Cancer Cell International

ISSN: 1475-2867

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