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Table 4 Relationships between different checkpoints

From: Lymphocyte activating gene 3 protein expression in nasopharyngeal carcinoma is correlated with programmed cell death-1 and programmed cell death ligand-1, tumor-infiltrating lymphocytes

Characteristics LAG-3 expression on TILs
High (> 14) Low (≤ 14) p value
PD-1 expression on TILs, n (%)
 High (> 2) 79 (43.4) 11 (6.0) 0.018
 Low (≤ 2) 68 (37.4) 24 (13.2) (1.157–5.5)
PD-L1 expression on TC, n (%)
 High (> 9) 25 (13.7) 14 (7.7) 0.003
 Low (≤ 9) 122 (67) 21 (11.6)  
PD-L1 expression on TILs, n (%)
 High (> 1%) 130 (71.4) 24 (13.2) 0.003
 Low (≤ 1%) 17 (8.9) 11 (6.5)  
CD3+ TIL, n (%)
 High (> 215) 105 (57.7) 20 (11) 0.101
 Low (≤ 215) 42 (23.1) 15 (8.2)  
GZMB, n (%)
 High (> 112) 39 (21.4) 5 (3.3) 0.128
 Low (≤ 112) 108 (58.8) 30 (16.5)  
  1. All the p values marked in bold are less than 0.05, which is statistically significant
  2. LAG-3: lymphocyte activating 3; CI: confidence interval; PD-L1: programmed death ligand 1; PD-1: programmed death 1; TIL: tumor-infiltrating lymphocyte; TC: tumor cell; GZMB: granzyme B