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Fig. 2 | Cancer Cell International

Fig. 2

From: The regulatory role of antisense lncRNAs in cancer

Fig. 2

In the nucleus, antisense lncRNAs exert their roles through DNA methylation, histone modification and transcriptional gene regulation. a MCM3AP-AS1 recruits DNMT1/DNMT3 to the promoter of NPY1R, resulting DNA methylation. b FOXD2-AS1 interacts with EZH2 and LSD1 and recruits them to the promoter region of EphB3, respectively guiding H3K27 methylation and H3K4 demethylation. c PAXIP1-AS1 recruits transcription factor ETS1 to the promoter of KIF14 and further affects its transcription

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Cancer Cell International

ISSN: 1475-2867

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