Fig. 5

XDH expression was correlated with high immune cytotoxic activity. A Gene ontology (GO) enrichment analysis showing the significantly affected GO items. GO terms with P values less than 0.05 were considered significantly enriched. B–E Gene set enrichment analysis (GSEA) of the Kyoto Encyclopedia of Genes and Genomes (KEGG) database showed that the purine metabolism pathway, T cell receptor pathway, PI3K-Akt pathway and MAPK pathway were activated. F Western blot analysis of the expression of XDH and PI3K-AKT pathway proteins. G–L IHC showed the correlation between the protein levels of XDH and those of other immune cell markers