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Fig. 7 | Cancer Cell International

Fig. 7

From: LINC01605, regulated by the EP300-SMYD2 complex, potentiates the binding between METTL3 and SPTBN2 in colorectal cancer

Fig. 7

LINC01605 harbors a positive correlation with SPTBN2 expression in CC patients. A expression of SPTBN2 in multiple TCGA databases. B expression of SPTBN2 mRNA in tumor tissues and ADJ tissues of 134 CC patients by RT-qPCR. C immunohistochemistry staining of SPTBN2 in cancer and ADJ tissues of CC patients. D Spearman's correlation analysis of the staining intensity of SPTBN2 with the expression of LINC01605 in CC tissues. E SPTBN2 expression in tumor tissues of patients with or without recurrence by RT-qPCR. F the correlation between the expression of LINC01605 and the clinical phenotype of 134 patients. G Kaplan–Meier analysis of the correlation between SPTBN2 expression and survival in 134 patients with CC. H Spearman's correlation analysis of the expression of SPTBN2 with the levels of CEA and CA199, tumor markers of CC in patients’ serum. I analysis of m6A modification levels of SPTBN2 mRNA in tumor tissues and ADJ tissues by MeRIP-qPCR. J correlation between the m6A modification level of SPTBN2 mRNA and the expression of LINC01605. Error bars represent means ± SD for three independent experiments (**p < 0.01, paired or unpaired t test, one-way ANOVA, followed by Tukey’s multiple comparison)

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Cancer Cell International

ISSN: 1475-2867

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