Circular RNAs and their role in renal cell carcinoma: a current perspective

Table 2 CircRNAs with oncogenic functions in RCC

CircRNA	Target miRNA/gene axis	Gene/Protein activity	Functions in RCC	Ref
circPCNXL2	miR-153/ZEB2	Increased	Increased proliferation and invasion	[73]
circ0039569	miR-34a-5p/CCL22	Increased	Increased proliferation, migration and invasion	[72]
circZNF609	miR-138-5p/FOXP4	Increased	Increased proliferation and invasion	[75]
circFNDC3B	miR-99a/JAK1/STAT3/MEK/ERK	Increased	Increased proliferation and migration	[76]
circNRIP1	miR-505/AMPK/PI3K/AKT/mTOR	Increased	Increased proliferation and migration	[77]
circ001895	miR-296-5p/SOX12	Increased	Increased proliferation, migration, invasion and decreased apoptosis	[78]
circEGLN3	miR-1299/IRF7	Increased	Increased proliferation, migration, invasion and decreased apoptosis	[79]
circABCB10	–	–	Increased proliferation and migration decreased apoptosis	[80]
circ000926	miR-411/CDH2	Increased	Increased proliferation, migration, invasion and EMT	[85]
circPRRC2A	miR-514a-5p miR-6776-5p/TRPM3	Increased	Increased proliferation and EMT	[69]
circ0035483	miR-335/CCNB1	Increased	Increased proliferation, autophagy and resistance to Gemcitabine	[70]

ISSN: 1475-2867