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Table 2 HER2-based immunotoxins in cancer therapy

From: Recombinant immunotoxins development for HER2-based targeted cancer therapies

Immunotoxin Targeting moiety Toxic moiety Origin of toxic moiety Additional attribute Mechanism of action Refs.
PEA-based rIT
 4D5scFv-PE40 4D5scFv PEA, PE40 Pseudomonas aeruginosa Mono-ADP-ribosyltransferases [71]
 HER2-PE25-X7 ZHER2:2891 PEA, PE25-X7 Pseudomonas aeruginosa Mono-ADP-ribosyltransferases [72]
 ADAPT6-ABD-PE38X8 ADAPT6 PEA, PE38X8 Pseudomonas aeruginosa ABD Mono-ADP-ribosyltransferases [73]
 ZHER2:2891-ABD-PE38X8 ZHER2:2891 Affibody PEA, PE38X8 Pseudomonas aeruginosa ABD Mono-ADP-ribosyltransferases [74]
 ZHER2:2891-ADAPT6-ABD-PE25 ZHER2:2891 Affibody, ADAPT6 PEA, PE25 Pseudomonas aeruginosa ABD, dual-targeting domain Mono-ADP-ribosyltransferases [75]
 5F7-PE24 X7 5F7 sdAb PEA, PE24 X7 Pseudomonas aeruginosa G4S spacer Mono-ADP-ribosyltransferases [76]
 11A4-PE24 X7 11A4 sdAb PEA, PE24X7 Pseudomonas aeruginosa G4S spacer Mono-ADP-ribosyltransferases [76]
 47D5-PE24X7 47D5 sdAb PEA, PE24X7 Pseudomonas aeruginosa G4S spacer Mono-ADP-ribosyltransferase [76]
 DARPin-LoPE DARPin LoPE Pseudomonas aeruginosa Mono-ADP-ribosyltransferase [77]
RIP-based rIT
 RTA-4D5-KDEL   Ricin Ricinus communis ER-targeting peptide KDEL N-Glycosidase [78]
 4D5/rGel 4D5scFv Gelonin Gelonium multiflorum N-Glycosidase [79]
 Fab–Gelonin Trastuzumab Fab Gelonin Gelonium multiflorum Sortase A trasnpeptidase N-Glycosidase [80]
 Trastuzumab–saporin Trastuzumab Saporin Saponaria officinalis N-Glycosidase [81]
 T-CUS245C Trastuzumab CUS245C Cucurbita moschata N-Glycosidase [82]
ImmunoRNase
 ScFv 4D5-dibarnase 4D5scFv Barnase Bacillus amyloliquefaciens RNase activity [83]
 hERB-hRNase anti-ErbB-2 scFv HP-RNase Human RNase activity [84]
 Erb-hcAb-RNase Erb-hcAb HP-RNase Human RNase activity, ADCC, CDC [85]
ERB–HP-DDADD-RNase Erbicin scFv HP-RNase Human RNase activity [86]
Immunoapoptotin
 GrbR201K-scFv1711 scFv GrB Human Serine protease [87]
 GrB-4D5-26 4D5 scFv GrB Human pH-sensitive peptide 26 Serine protease [88]
 GrB-Fc-4D5 4D5 scFv GrB Human IgG Fc linker Serine protease [89]
 GrB-FRP5 FRP5 scFv GrB Human Serine protease [90]
 FRP5-ETA252–366-AIFΔ100 FRP5 scFv AIF Human Translocation domain of PEA Apoptosis effector [91]
 Immunocasp-6 e23sFv Active caspase-6 Human Translocation domain of PEA Apoptosis effector [92]
 HER-PE-CP3 e23sFv C-cp-3 Human Translocation domain of PEA Apoptosis effector [93]
 HusFv-Fdt-tBid e23sFv tBid Human Fdt linker Apoptosis effector [94]
 e23sFv-TD-tBiD e23sFv tBid Human DT translocation domain Apoptosis effector [95]
Immunophotosensitizer
 4D5scFv-KillerRed scFv KillerRed Hydrozoa jellyfish ROS production [96]
 4D5scFv-miniSOG scFv miniSOG Arabidopsis ROS production [97]
 DARPin-miniSOG DARPin miniSOG Arabidopsis ROS production [98]
  1. ABD albumin binding domain, ADCC antibody-dependent cellular cytotoxicity, AIF apoptosis inducing factor, CDC complement-dependent cytotoxicity, DT diphtheria toxin, Erb-hcAb Erbicin-human-compact antibody, GrB granzyme B, PEA pseudomonas exotoxin A, ROS reactive oxygen species, tBid truncated Bid