From: Recombinant immunotoxins development for HER2-based targeted cancer therapies
Immunotoxin | Targeting moiety | Toxic moiety | Origin of toxic moiety | Additional attribute | Mechanism of action | Refs. |
---|---|---|---|---|---|---|
PEA-based rIT | ||||||
 4D5scFv-PE40 | 4D5scFv | PEA, PE40 | Pseudomonas aeruginosa | – | Mono-ADP-ribosyltransferases | [71] |
 HER2-PE25-X7 | ZHER2:2891 | PEA, PE25-X7 | Pseudomonas aeruginosa | – | Mono-ADP-ribosyltransferases | [72] |
 ADAPT6-ABD-PE38X8 | ADAPT6 | PEA, PE38X8 | Pseudomonas aeruginosa | ABD | Mono-ADP-ribosyltransferases | [73] |
 ZHER2:2891-ABD-PE38X8 | ZHER2:2891 Affibody | PEA, PE38X8 | Pseudomonas aeruginosa | ABD | Mono-ADP-ribosyltransferases | [74] |
 ZHER2:2891-ADAPT6-ABD-PE25 | ZHER2:2891 Affibody, ADAPT6 | PEA, PE25 | Pseudomonas aeruginosa | ABD, dual-targeting domain | Mono-ADP-ribosyltransferases | [75] |
 5F7-PE24 X7 | 5F7 sdAb | PEA, PE24 X7 | Pseudomonas aeruginosa | G4S spacer | Mono-ADP-ribosyltransferases | [76] |
 11A4-PE24 X7 | 11A4 sdAb | PEA, PE24X7 | Pseudomonas aeruginosa | G4S spacer | Mono-ADP-ribosyltransferases | [76] |
 47D5-PE24X7 | 47D5 sdAb | PEA, PE24X7 | Pseudomonas aeruginosa | G4S spacer | Mono-ADP-ribosyltransferase | [76] |
 DARPin-LoPE | DARPin | LoPE | Pseudomonas aeruginosa | – | Mono-ADP-ribosyltransferase | [77] |
RIP-based rIT | ||||||
 RTA-4D5-KDEL |  | Ricin | Ricinus communis | ER-targeting peptide KDEL | N-Glycosidase | [78] |
 4D5/rGel | 4D5scFv | Gelonin | Gelonium multiflorum | – | N-Glycosidase | [79] |
 Fab–Gelonin | Trastuzumab Fab | Gelonin | Gelonium multiflorum | Sortase A trasnpeptidase | N-Glycosidase | [80] |
 Trastuzumab–saporin | Trastuzumab | Saporin | Saponaria officinalis | – | N-Glycosidase | [81] |
 T-CUS245C | Trastuzumab | CUS245C | Cucurbita moschata | – | N-Glycosidase | [82] |
ImmunoRNase | ||||||
 ScFv 4D5-dibarnase | 4D5scFv | Barnase | Bacillus amyloliquefaciens | – | RNase activity | [83] |
 hERB-hRNase | anti-ErbB-2 scFv | HP-RNase | Human | – | RNase activity | [84] |
 Erb-hcAb-RNase | Erb-hcAb | HP-RNase | Human | – | RNase activity, ADCC, CDC | [85] |
ERB–HP-DDADD-RNase | Erbicin scFv | HP-RNase | Human | – | RNase activity | [86] |
Immunoapoptotin | ||||||
 GrbR201K-scFv1711 | scFv | GrB | Human | – | Serine protease | [87] |
 GrB-4D5-26 | 4D5 scFv | GrB | Human | pH-sensitive peptide 26 | Serine protease | [88] |
 GrB-Fc-4D5 | 4D5 scFv | GrB | Human | IgG Fc linker | Serine protease | [89] |
 GrB-FRP5 | FRP5 scFv | GrB | Human | – | Serine protease | [90] |
 FRP5-ETA252–366-AIFΔ100 | FRP5 scFv | AIF | Human | Translocation domain of PEA | Apoptosis effector | [91] |
 Immunocasp-6 | e23sFv | Active caspase-6 | Human | Translocation domain of PEA | Apoptosis effector | [92] |
 HER-PE-CP3 | e23sFv | C-cp-3 | Human | Translocation domain of PEA | Apoptosis effector | [93] |
 HusFv-Fdt-tBid | e23sFv | tBid | Human | Fdt linker | Apoptosis effector | [94] |
 e23sFv-TD-tBiD | e23sFv | tBid | Human | DT translocation domain | Apoptosis effector | [95] |
Immunophotosensitizer | ||||||
 4D5scFv-KillerRed | scFv | KillerRed | Hydrozoa jellyfish | – | ROS production | [96] |
 4D5scFv-miniSOG | scFv | miniSOG | Arabidopsis | – | ROS production | [97] |
 DARPin-miniSOG | DARPin | miniSOG | Arabidopsis | – | ROS production | [98] |