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Table 2 HER2-based immunotoxins in cancer therapy

From: Recombinant immunotoxins development for HER2-based targeted cancer therapies

Immunotoxin

Targeting moiety

Toxic moiety

Origin of toxic moiety

Additional attribute

Mechanism of action

Refs.

PEA-based rIT

 4D5scFv-PE40

4D5scFv

PEA, PE40

Pseudomonas aeruginosa

Mono-ADP-ribosyltransferases

[71]

 HER2-PE25-X7

ZHER2:2891

PEA, PE25-X7

Pseudomonas aeruginosa

Mono-ADP-ribosyltransferases

[72]

 ADAPT6-ABD-PE38X8

ADAPT6

PEA, PE38X8

Pseudomonas aeruginosa

ABD

Mono-ADP-ribosyltransferases

[73]

 ZHER2:2891-ABD-PE38X8

ZHER2:2891 Affibody

PEA, PE38X8

Pseudomonas aeruginosa

ABD

Mono-ADP-ribosyltransferases

[74]

 ZHER2:2891-ADAPT6-ABD-PE25

ZHER2:2891 Affibody, ADAPT6

PEA, PE25

Pseudomonas aeruginosa

ABD, dual-targeting domain

Mono-ADP-ribosyltransferases

[75]

 5F7-PE24 X7

5F7 sdAb

PEA, PE24 X7

Pseudomonas aeruginosa

G4S spacer

Mono-ADP-ribosyltransferases

[76]

 11A4-PE24 X7

11A4 sdAb

PEA, PE24X7

Pseudomonas aeruginosa

G4S spacer

Mono-ADP-ribosyltransferases

[76]

 47D5-PE24X7

47D5 sdAb

PEA, PE24X7

Pseudomonas aeruginosa

G4S spacer

Mono-ADP-ribosyltransferase

[76]

 DARPin-LoPE

DARPin

LoPE

Pseudomonas aeruginosa

Mono-ADP-ribosyltransferase

[77]

RIP-based rIT

 RTA-4D5-KDEL

 

Ricin

Ricinus communis

ER-targeting peptide KDEL

N-Glycosidase

[78]

 4D5/rGel

4D5scFv

Gelonin

Gelonium multiflorum

N-Glycosidase

[79]

 Fab–Gelonin

Trastuzumab Fab

Gelonin

Gelonium multiflorum

Sortase A trasnpeptidase

N-Glycosidase

[80]

 Trastuzumab–saporin

Trastuzumab

Saporin

Saponaria officinalis

N-Glycosidase

[81]

 T-CUS245C

Trastuzumab

CUS245C

Cucurbita moschata

N-Glycosidase

[82]

ImmunoRNase

 ScFv 4D5-dibarnase

4D5scFv

Barnase

Bacillus amyloliquefaciens

RNase activity

[83]

 hERB-hRNase

anti-ErbB-2 scFv

HP-RNase

Human

RNase activity

[84]

 Erb-hcAb-RNase

Erb-hcAb

HP-RNase

Human

RNase activity, ADCC, CDC

[85]

ERB–HP-DDADD-RNase

Erbicin scFv

HP-RNase

Human

RNase activity

[86]

Immunoapoptotin

 GrbR201K-scFv1711

scFv

GrB

Human

Serine protease

[87]

 GrB-4D5-26

4D5 scFv

GrB

Human

pH-sensitive peptide 26

Serine protease

[88]

 GrB-Fc-4D5

4D5 scFv

GrB

Human

IgG Fc linker

Serine protease

[89]

 GrB-FRP5

FRP5 scFv

GrB

Human

Serine protease

[90]

 FRP5-ETA252–366-AIFΔ100

FRP5 scFv

AIF

Human

Translocation domain of PEA

Apoptosis effector

[91]

 Immunocasp-6

e23sFv

Active caspase-6

Human

Translocation domain of PEA

Apoptosis effector

[92]

 HER-PE-CP3

e23sFv

C-cp-3

Human

Translocation domain of PEA

Apoptosis effector

[93]

 HusFv-Fdt-tBid

e23sFv

tBid

Human

Fdt linker

Apoptosis effector

[94]

 e23sFv-TD-tBiD

e23sFv

tBid

Human

DT translocation domain

Apoptosis effector

[95]

Immunophotosensitizer

 4D5scFv-KillerRed

scFv

KillerRed

Hydrozoa jellyfish

ROS production

[96]

 4D5scFv-miniSOG

scFv

miniSOG

Arabidopsis

ROS production

[97]

 DARPin-miniSOG

DARPin

miniSOG

Arabidopsis

ROS production

[98]

  1. ABD albumin binding domain, ADCC antibody-dependent cellular cytotoxicity, AIF apoptosis inducing factor, CDC complement-dependent cytotoxicity, DT diphtheria toxin, Erb-hcAb Erbicin-human-compact antibody, GrB granzyme B, PEA pseudomonas exotoxin A, ROS reactive oxygen species, tBid truncated Bid