Fig. 2

The development of human multiple myeloma (MM) cells. a Pseudotemporal trajectory of human MM cells assigned to clusters 0–6 using the Monocle 2 algorithm; b Pseudotime ordering of MM cells was shown in a gradient from dark to light blue; c Developmental pseudotime reflecting the cell state transition of MM cells; d t-SNE coloured by the different states; e Venn diagram of different marker genes between early/middle stage and late stage; f Violin plots of the expression patterns of representative genes of the MM cells; g The expression patterns of representative genes of the early and late MM cells mapped on t-distributed stochastic neighbor embedding (t-SNE) plot