Fig. 2

Contralateral breast cancer: relative risk. A CRRM, CPI, and Contralateral breast cancer risk in unilateral breast cancer patients carrying BRCA1/2 mutation. B CRRM, CPI, and overall survival in unilateral breast cancer patients carrying BRCA1/2 mutation. C CRRM, CPI, and breast cancer-specific survival in unilateral breast cancer patients carrying BRCA1/2 mutation. The width of the horizontal line represents the 95% CI of the individual study, and the square proportional represents the weight of each study. The weight was calculated by the sample size of each individual study, and was presented by the percentage of total. The diamond represents the pooled RR and 95% CI. CBC contralateral breast cancer, CRRM contralateral risk-reducing mastectomy, CPI contralateral prophylactic irradiation