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Fig. 3 | Cancer Cell International

Fig. 3

From: Cancer and diabetes: the interlinking metabolic pathways and repurposing actions of antidiabetic drugs

Fig. 3

Schematic representation of anticancer and antidiabetic mechanism of sulfonylureas (SU). The binding of SU with sulphonylurea receptor (SUR) inhibits the efflux of K+, activates the influx of Ca2+ and induces the generation of reactive oxygen species (ROS). The accumulation of reactive oxygen species in turn results into apoptosis whereas increased influx of calcium (II) ions causes exocytosis of insulin by rearrangement of cytoskeleton. ATP adenosine triphosphate, ADP adenosine diphosphate

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Cancer Cell International

ISSN: 1475-2867

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