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Table 2 Univariate and multivariate analysis of DFS

From: Prognostic value of preoperative inflammatory markers in patients with hepatocellular carcinoma who underwent curative resection

Variable   Univariate analysis Multivariate analysis
  HR (95%CI) P value HR (95%CI) P value
Sex Male/female 1.401 (0.947–2.072) 0.092   
Age (years)  ≥ 60/ < 60 0.767 (0.560–1.050) 0.097   
HBsAg Positive/negative 1.317 (0.874–1.985) 0.189   
Liver cirrhosis Yes/no 1.080 (0.819–1.425) 0.586   
Portal vein invasion Yes/no 2.710 (1.686–4.357)  < 0.001   
Ascites Yes/no 2.997 (1.621–5.539)  < 0.001   
Ablation or TACE Yes/no 0.833 (0.637–1.089) 0.181   
AFP (ng/ml)  > 400/ ≤ 400 1.674 (1.279–2.190)  < 0.001 1.377 (1.042–1.821) 0.025
Tumor capsule No/yes 2.146 (1.497–3.078)  < 0.001 1.864 (1.289–2.697) 0.001
Tumor number  ≥ 2/1 1.481 (1.006–2.181) 0.047   
Tumor size (cm)  > 5/≤ 5 1.766 (1.348–2.313)  < 0.001 1.440 (1.090–1.901) 0.010
MVIa Yes/no 1.649 (1.259–2.160)  < 0.001 1.352 (1.022–1.789) 0.035
Cell differentiation Moderate/well 2.248 (1.189–4.251) 0.013   
Poor/well 2.869 (1.364–6.031) 0.005   
MKIb No/yes 0.596 (0.395–0.900) 0.014   
Child class B/A 1.683 (0.891–3.177) 0.109   
NLR  > 2.33/ ≤ 2.33 1.264 (0.965–1.656) 0.089   
PLR  > 117.09/ ≤ 117.09 1.270 (0.969–1.664) 0.083   
GPR  > 0.48/ ≤ 0.48 2.327 (1.770–3.060)  < 0.001 1.931 (1.445–2.581)  < 0.001
ALR  > 31/ ≤ 31 1.903 (1.455–2.488)  < 0.001 1.438 (1.083–1.910) 0.012
FAR  > 0.06/ ≤ 0.06 1.617 (1.234–2.117)  < 0.001   
  1. aMVI: microvascular invasion
  2. bMKI: multiple kinase inhibitor