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Table 2 Univariate and multivariate analysis of DFS

From: Prognostic value of preoperative inflammatory markers in patients with hepatocellular carcinoma who underwent curative resection

Variable

 

Univariate analysis

Multivariate analysis

 

HR (95%CI)

P value

HR (95%CI)

P value

Sex

Male/female

1.401 (0.947–2.072)

0.092

  

Age (years)

 ≥ 60/ < 60

0.767 (0.560–1.050)

0.097

  

HBsAg

Positive/negative

1.317 (0.874–1.985)

0.189

  

Liver cirrhosis

Yes/no

1.080 (0.819–1.425)

0.586

  

Portal vein invasion

Yes/no

2.710 (1.686–4.357)

 < 0.001

  

Ascites

Yes/no

2.997 (1.621–5.539)

 < 0.001

  

Ablation or TACE

Yes/no

0.833 (0.637–1.089)

0.181

  

AFP (ng/ml)

 > 400/ ≤ 400

1.674 (1.279–2.190)

 < 0.001

1.377 (1.042–1.821)

0.025

Tumor capsule

No/yes

2.146 (1.497–3.078)

 < 0.001

1.864 (1.289–2.697)

0.001

Tumor number

 ≥ 2/1

1.481 (1.006–2.181)

0.047

  

Tumor size (cm)

 > 5/≤ 5

1.766 (1.348–2.313)

 < 0.001

1.440 (1.090–1.901)

0.010

MVIa

Yes/no

1.649 (1.259–2.160)

 < 0.001

1.352 (1.022–1.789)

0.035

Cell differentiation

Moderate/well

2.248 (1.189–4.251)

0.013

  

Poor/well

2.869 (1.364–6.031)

0.005

  

MKIb

No/yes

0.596 (0.395–0.900)

0.014

  

Child class

B/A

1.683 (0.891–3.177)

0.109

  

NLR

 > 2.33/ ≤ 2.33

1.264 (0.965–1.656)

0.089

  

PLR

 > 117.09/ ≤ 117.09

1.270 (0.969–1.664)

0.083

  

GPR

 > 0.48/ ≤ 0.48

2.327 (1.770–3.060)

 < 0.001

1.931 (1.445–2.581)

 < 0.001

ALR

 > 31/ ≤ 31

1.903 (1.455–2.488)

 < 0.001

1.438 (1.083–1.910)

0.012

FAR

 > 0.06/ ≤ 0.06

1.617 (1.234–2.117)

 < 0.001

  
  1. aMVI: microvascular invasion
  2. bMKI: multiple kinase inhibitor