Fig. 5

LBX2-AS1 bolsters CRC cell resistance to 5-FU. A The expression of LBX2-AS1 was measured in 5-FU-treated CRC cells (B) LBX2-AS1 silencing was conducted in CRC cells. B The viability and 5-FU IC50 values were determined for the indicated CRC cells. C qPCR was used to assess P-gp, MRP1, and BCRP expression in the indicated cells. D LBX2-AS1 expression in 5-FU-sensitive and -resistant CRC patients from cohort B. For A–D, mean ± s.e.m. were derived from n = 3 independent experiments *P < 0.05; **P < 0.01; ***P < 0.001; Student’s t-test