Fig. 4
From: EZR promotes pancreatic cancer proliferation and metastasis by activating FAK/AKT signaling pathway
Bioinformatics analysis predicted the biological function of EZR. A GO enriched the cellular component organization (CC), biological process (BP) and molecular function (MF). The results showed EZR was involved in cell adhesion molecule binding, focal adhesion, ameboidal-type cell migration, regulation of cell morphogenesis and etc. B The protein–protein interaction (PPI) network of EZR was constructed using STRING. C–E GSEA showed pathways involved in the EZR enrichment analysis: adherens junction, pathways in cancers and especially in pancreatic cancer were selected as candidates. The data was analyzed from TCGA-PAAD database and demonstrated by Cytoscape. F Multi GSEA enrichment showed the higher expression of EZR could strongly active the five signaling pathways