Fig. 5

Cancer patient survival analysis of representative top-ranked CREB1 target genes. A–D Kaplan–Meier overall survival curves of top-ranked CREB1-upregulated targets (BDKRB2, HOXA4, CLGN, VGF) in different cancer types. E Kaplan–Meier overall survival curve of a top-ranked CREB1-downregulated target, SERPINI1, in different cancer types. log rank p value ≤ 0.05 was considered significant. Hazard ratio (HR) ≥ 1 and p (HR)  <  0.05 were considered significantly poor prognosis. n (high) and n (low) are the patient number