Prognostic impact of tertiary lymphoid structures in breast cancer prognosis: a systematic review and meta-analysis

Table 3 The fisher's method combine p-value analysis of the correlation between TLS and various clinicopathological parameters and gene expression

Parameters	No. of cohorts	Number of cases	χ² value	p	Relationship with TLSs
Patients’ age	4	665	5.332	0.722	No statistical significance
Tumor size	4	665	4.149	0.843	No statistical significance
Tumor differentiation	6	1117	70.765	< 0.001	Negative
pTNM stage,	2	250	19.690	< 0.001	Negative
Lymph node metastasis	5	913	31.939	< 0.001	Negative
TILs density	2	373	27.631	< 0.001	Positive
HER2	4	867	42.448	< 0.001	Positive
ER	3	663	33.098	< 0.001	Negative
PR	3	663	35.455	< 0.001	Negative
Ki67	2	373	13.468	0.009	Positive

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