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Fig. 5 | Cancer Cell International

Fig. 5

From: FAM49B promotes breast cancer proliferation, metastasis, and chemoresistance by stabilizing ELAVL1 protein and regulating downstream Rab10/TLR4 pathway

Fig. 5

Changes in gene expressions in MDA-MB-231 cells with FAM49B knockdown, analyzed using microarray. A Heat-map analysis showing 1063 genes that were detected as being altered, by microarray profiling. p < 0.05 and |fold Change|≥ 1.5. B, C Disease and function enrichment of whole-genome expression microarray in FAM49B knockdown MDA-MB-231 cells was performed using IPA. D Canonical pathway enrichment of whole-genome expression microarray in FAM49B knockdown MDA-MB-231 cells was performed using IPA. E Gene interaction network of FAM49B and related genes in Toll-like receptor signaling pathway. The results show that Rab10, TLR4, and ELAVL1 (shown in red frame) were located in the central regulatory position. Data are shown as mean ± SD

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Cancer Cell International

ISSN: 1475-2867

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