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Fig. 9 | Cancer Cell International

Fig. 9

From: miR-140-3p is involved in the occurrence and metastasis of gastric cancer by regulating the stability of FAM83B

Fig. 9

Overexpression of miR-140-3p inhibited the growth and metastasis of GC. Nude-mice transplanted tumor models were established using AGS cells with overexpression of miR-140-3p and SNHG12. A representative image of the transplanted tumor. B the volume of the tumor. C the weight of the tumor after euthanasia of nude mice on day 12. D, E The positive rates of ki67 and HuR in tumor tissues were detected by immunocytochemistry. F The level of SNHG12 and FAM83B in tumor tissues was detected by RT-qPCR. G The metastasis of GC was observed using vivo imaging of small animals. H The number of pulmonary metastasis was observed using HE staining. N = 6. Data in panels C/D/E were presented as mean ± standard deviation. Comparison between data in panels C–H was analyzed using the t-test. Comparison among data in panel B was analyzed by using two-way ANOVA, followed by Tukey's multiple comparisons test. **p < 0.01. LV-oe-miR: the lentiviral overexpression vector of miR-140-3p; LV-NC: The lentiviral overexpression vector of NC; LV-SNHG12: The lentiviral overexpression vector of SNHG12

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Cancer Cell International

ISSN: 1475-2867

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