Table 3 Univariate and multivariate analyses of risk factors influencing OS after liver resection
Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95 % CI) | P value | HR (95% CI) | P value | |
Age (> 60 years vs. ≤ 60 years) | 0.745 (0.384−1.443) | 0.382 |  |  |
Sex (Male vs. Female) | 1.056 (0.550−2.027) | 0.870 |  |  |
Primary tumor location (Rectum vs. Colon) | 2.565 (1.355−4.854) | 0.004 | 2.777 (1.371−5.626) | 0.005 |
Primary tumor differentiation (Poor vs. Well to moderate) | 1.000 (0.458−2.182) | 0.999 |  |  |
T stage (T4 vs. T1-3) | 2.185 (1.145-4.169) | 0.018 | 1.241 (0.598-2.576) | 0.562 |
 N stage (N1−2 vs. N0) | 3.067 (1.663−5.656) | < 0.001 | 3.421 (1.493−7.841) | 0.004 |
Timing of liver metastasis (Synchronous vs. Metachronous) | 2.955 (1.346−6.488) | 0.007 | 0.957 (0.465−1.967) | 0.904 |
TBS (>3 vs. ≤3) | 1.315 (0.696−2.485) | 0.399 |  |  |
Adjuvant chemotherapy after liver resection (Yes vs. No) | 0.845 (0.423−1.689) | 0.634 |  |  |
DNA ploidy (Nondiploid vs. diploid) | 2.855 (1.013−8.049) | 0.047 | 2.751 (0.971-7.795) | 0.057 |
Stroma fraction (High stroma vs. low stroma) | 0.984 (0.513−1.889) | 0.962 |  |  |
Nucleotyping (Chromatin heterogeneous vs. Chromatin homogeneous) | 0.924 (0.481−1.774) | 0.812 |  |  |