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Table 3 Multivariate Cox regression analysis of prognostic factors of HNSCC

From: Hypomethylation and downregulation of miR-23b-3p are associated with upregulated PLAU: a diagnostic and prognostic biomarker in head and neck squamous cell carcinoma

Variable

OS

RR

95% CI

p-value

Sex (male/female)

0.745

(0.536, 1.038)

0.082

Age, years (≥ 60/ < 60)

0.823

(0.607, 1.117)

0.211

Smoking status (yes/no)

1.065

(0.732, 1.549)

0.742

Tumor stage (T1/T2/T3/T4)

0.865

(0.710, 1.054)

0.150

Lymph metastasis (N0/N1/N2)

1.012

(0.839, 1.221)

0.901

Clinical stage (I/II/III/IV)

1.531

(1.194, 1.963)

0.001*

PLAU expression (high/low)

1.639

(1.216, 2.209)

0.001*

  1. OS overall survival, RR relative risk, CI confidence interval
  2. *p < 0.05