Fig. 5

Methylation level of CTHRC1 DNA in different tumors and its association with gene expression. a–c Promoter methylation levels of CTHRC1 in different cancer types compared to normal adjacent tissues. The Beta value indicates level of DNA methylation ranging from 0 (unmethylated) to 1 (fully methylated). Different beta value cut-off has been considered to indicate hyper-methylation [Beta value: 0.7—0.5] or hypo-methylation [Beta-value: 0.3—0.25]. d The relationship between the CTHRC1 mRNA expression (RNA-seq or Affy) and DNA methylation in glioma in CCLE database. e We used the MEXPRESS approach to analyze the DNA methylation level of CTHRC1 with multiple probes. The promoter region probes are highlighted by red rectangle. The beta value of methylation, the Benjamini-Hochberg-adjusted P-value and the Pearson correlation coefficients (R) are displayed