Fig. 7
From: Dysregulation of the miR-30a/BiP axis by cigarette smoking accelerates oral cancer progression
CSC stimulated BiP expression and malignant behaviors by downregulating miR-30a. CSC promoted cell invasion and tumor-associated angiogenesis by inducing the expression of BiP. Mechanistically, downregulation of miR-30a was involved in the epigenetic regulation of BiP expression in OSCC cells after exposure to CSC. In addition, BiP stimulated malignant behaviors of CSC-exposed OSCC cells through increased VEGF production and secretion