Fig. 5

Prediction and PPI network of the upstream kinases of the differentially expressed phosphoproteins between the IL-6 group and the Lob group. a In total, 93 kinase-substrate interactions were predicted using NetPhos 3.1 according to the differentially expressed phosphoproteins and the specific phosphosites. b PPIs of the predicted kinases. PPI network analysis was performed using the STRING database. The blue lines show the interactions obtained from the curated database; the purple lines show the interactions that were experimentally determined; the dark green lines indicate the gene neighborhood; the light green lines show the text mining interactions; the red lines indicate gene fusions; and the light violet lines show protein homologies