Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells

Table 1 Differentially expressed phosphoproteins between the IL-6 group and the Lob group

Phosphoprotein names	Protein accessions	Gene Names	Fold-change	Up/down	P-value
28S ribosomal protein S17, mitochondrial	Q9Y2R5	MRPS17	1.610	Up	0.0284
Filamin-C	Q14315	FLNC	1.264	Up	0.000664
NSFL1 cofactor p47	Q9UNZ2	NSFL1C	1.248	Up	0.0337
ESF1 homolog	Q9H501	ESF1	1.233	Up	0.00661
Neuroblast differentiation-associated protein AHNAK	Q09666	AHNAK	1.214	Up	0.00374
Caspase-7	P55210	CASP7	0.828	Down	0.00626
Cytospin-A	Q69YQ0	SPECC1L	0.825	Down	0.0233
Scm-like with four MBT domains protein 1	Q9UHJ3	SFMBT1	0.819	Down	0.00401
Eukaryotic translation initiation factor 2 subunit 2	P20042	EIF2S2	0.805	Down	0.0170
EH domain-containing protein 2	Q9NZN4	EHD2	0.804	Down	0.0182
Centrosome and spindle pole-associated protein 1	Q1MSJ5	CSPP1	0.798	Down	0.0132
DnaJ homolog subfamily C member 9	Q8WXX5	DNAJC9	0.793	Down	0.0184
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	Q9Y3Z3	SAMHD1	0.787	Down	0.0343
Akirin-1	Q9H9L7	AKIRIN1	0.785	Down	0.0156
TP53-binding protein 1	Q12888	TP53BP1	0.781	Down	0.0337
Serine/threonine-protein kinase 26	Q9P289	STK26	0.778	Down	0.0331
Transcriptional activator protein Pur-beta	Q96QR8	PURB	0.768	Down	0.0114
DNA repair protein complementing XP-C cells	Q01831	XPC	0.762	Down	0.0448
Pentatricopeptide repeat domain-containing protein 3, mitochondrial	Q96EY7	PTCD3	0.744	Down	0.0371
Shugoshin 1	Q5FBB7	SGO1	0.738	Down	0.0259
Fos-related antigen 2	P15408	FOSL2	0.719	Down	0.0138
TNF receptor-associated factor 2	Q12933	TRAF2	0.634	Down	0.0385

ISSN: 1475-2867