Table 3 Unadjusted and multivariate analyses for overall survival (2-category stroma-immune score)
Development group | Internal validation group | External validation group | |||||||
|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
Unadjusted stratified Cox model | |||||||||
Stroma-immune score | |||||||||
Low | 1 | 1 | 1 | ||||||
High | 0.39 | 0.24–0.63 | < 0.001 | 0.49 | 0.28–0.88 | 0.017 | 0.35 | 0.15–0.83 | 0.018 |
Multivariable stratified Cox model | |||||||||
Stroma-immune score | |||||||||
Low | 1 | 1 | 1 | ||||||
High | 0.40 | 0.24–0.66 | < 0.001 | 0.52 | 0.29–0.93 | 0.027 | 0.37 | 0.15–0.89 | 0.027 |
TNM stage | |||||||||
II | 1 | 1 | 1 | ||||||
III | 3.31 | 1.80–6.09 | < 0.001 | 2.68 | 1.42–5.04 | 0.002 | 1.79 | 0.76–4.22 | 0.184 |
Age | 1.04 | 1.01–1.06 | 0.006 | 1.02 | 0.99–1.04 | 0.151 | 1.03 | 1.00–1.07 | 0.072 |