Fig. 5
From: YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells
Knockdown of VPS25 represses glioma growth in vivo. A A xenograft murine model was built using the U87MG cells transfected with VPS25 stable knockdown (sh-VPS25) or control (sh-NC). The glioma volume curves were detected in sh-VPS25 and sh-NC groups for 30 days. B Tumors were collected from nude mice (sh-VPS25 and sh-NC) at 30 days. C Statistics of the weight of the tumors in B. D The VPS25 protein expression in sh-VPS25 and sh-NC groups was detected by western blot. E The VPS25 protein expression in sh-VPS25 and sh-NC groups was detected by immunohistochemistry. The results are shown as the mean ± SD. **P < 0.01, ***P < 0.001