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Fig. 5 | Cancer Cell International

Fig. 5

From: Promotion of gastric tumor initiating cells in a 3D collagen gel culture model via YBX1/SPP1/NF-κB signaling

Fig. 5

Blockade of ITGB1/ NF-κB signals revealed improved outcome in gastric cancer therapy. A Tumor volumes of SGC-7901 bearing mice treated with PBS, LDV, PTX and LDV combining PTX. B Survival time of SGC-7901 bearing mice treated with PBS, LDV, PTX and LDV combining PTX. C Tumor volumes of 3D collagen cultured SGC-7901 bearing mice treated with PBS, LDV, PTX and LDV combining PTX. D Survival time of 3D collagen cultured SGC-7901 bearing mice treated with PBS, LDV, PTX and LDV combining PTX. E Immunofluorescence of ITGB1 and NF-κB in tumor tissues from SGC-7901 bearing mice and 3D collagen cultured SGC-7901 bearing mice on day 15. The scale bar is 50 μm. F immunofluorescence of ITGB1 and NF-κB in tumor tissues from 3D collagen cultured SGC-7901 bearing mice on day 30 (treated with PBS, LDV, PTX, LDV combining PTX). The scale bar is 50 μm. G Tumor volumes of 3D collagen cultured SGC-7901 bearing mice treated with PBS, JSH-23, PTX and JSH-23 combining PTX. H Survival time of 3D collagen cultured SGC-7901 bearing mice treated with PBS, JSH-23, PTX and JSH-23 combining PTX

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Cancer Cell International

ISSN: 1475-2867

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