Table 1 Baseline characteristics of included studies
Author | Year | Country | Induction treatment | Conditioning regimens | No. patients | Follow-up (m) Median (range) | Maintenance treatment (n) | ≥ VGPR pre-ASCT (n) |
|---|---|---|---|---|---|---|---|---|
Bashir [15] | 2019 | USA | VRD, VCD, KRD, VD, CBAD, RD | Busulfan 32 mg/m2, Day-7 to -4, iv; Melphalan 70 mg/m2/d, Day-2 to -1 | 104 | 22.6 (IQR 15.2–47.1) | 87 | 54 |
Melphalan 200 mg/m2, Day-2 | 98 | 20.2 (IQR 8.8–46.6) | 84 | 56 | ||||
2019 | Spain | VBMCP, VBAD, VAD | Busulfan 3.2 mg/kg/d, Day-5 to -3, iv; Melphalan 140 mg/m2, Day-2 | 51 | 50 | 33 | – | |
Melphalan 100 mg/m2/d, Day-3 to -2 or 200 mg/m2, Day-2 | 102 | 63 | 65 | – | ||||
Byun [14] | 2018 | Korea | – | Combined busulfan (iv) and melphalan | 107 | mean 37.6 (SD 17.9) | – | – |
Melphalan 200 mg/m2 | 428 | mean 37.5 (SD 28.1) | – | – | ||||
Galindo R [31] | 2006 | Spain | - | Busulfan 16 mg/kg, iv; Melphalan 140 mg/m2 | 20 | – | – | – |
Melphalan 200 mg/m2 | 23 | – | – | – | ||||
Hagen P [30] | 2020 | USA | - | Busulfan 130 mg/m2/d, Day-6 to -3, iv; Melphalan 140 mg/m2, Day-2; Bortezomib 1.6 mg/m2, Day-1 | 43 | 86 (5–109) | 0 | 18 |
Melphalan 200 mg/m2, Day-2 | 162 | 85 (1–121) | 121 | 76 | ||||
Lahuerta [27] | 2002 | Spain | – | Busulfan 3 mg/kg/d, Day –6 to –3, orally; Melphalan 140 mg/m2, Day–2 | 186 | - | 80 | – |
Melphalan 100 mg/m2/d, Day-3 to -2 or 200 mg/m2 Day-2 | 472 | - | 184 | – | ||||
Lahuerta JJ [28] | 2010 | Spain | VBMCP, VBAD | Busulfan 3 mg/kg/d, Day–6 to –3, orally; Melphalan 140 mg/m2, Day –2 | 225 | 72 | – | – |
Melphalan 100 mg/m2/d, Day -3 to -2 or 200 mg/m2 Day -2 | 542 | 47 | – | – | ||||
Park [12] | 2021 | Korea | VTD | Busulfan 3.2 mg/kg/d, Day -6 to -4, iv; Melphalan 70 mg/m2/d, Day -3 to -2 | 31 | 22.4 | 13 | 16 |
Melphalan 100 mg/m2/d, Day-3 to -2 | 79 | 34.2 | 2 | 53 | ||||
Ria [29] | 2004 | Italy | VAD | Busulfan 4 mg/kg/d, Day-7 to -4; Melphalan 100 mg/m2, Day-3 | 14 | – | 14 | – |
Melphalan 200 mg/m2, Day-1 | 16 | – | 16 | – | ||||
Song [13] | 2020 | Korea | TD, CTD | Busulfan 3.2 mg/kg/d, Day -6 to -4, iv; Melphalan 70 mg/m2/d, Day-3 to -2. | 76 | 37.3 | 29 | 37 |
Melphalan 100 mg/m2/d, Day-3 to -2 | 76 | 50.8 | 18 | 43 |