Fig. 2From: Comprehensive analysis of CXCL12 expression reveals the significance of inflammatory fibroblasts in bladder cancer carcinogenesis and progressionThe decrease of iCAFs accompanied BLCA pathogenesis. A The expression of marker genes for iCAFs was significantly reduced in BLCA compared with normal tissues. B GO and KEGG enrichment analysis indicated decreased extracellular matrix in BLCA, further suggesting reduced fibroblasts in BLCA pathogenesis. C ROC curves showed high diagnostic values of various iCAFs marker genes. D Immunohistochemistry assays confirmed the reduction of iCAFs markers in BLCA, including CXCL12, PDGFRA and VIMBack to article page