Table 1 Study characteristics
Study ID | Country | Cancer type | Sample size | Sample source | Detection method | Criterion of low expression | Antibody | NOS score |
|---|---|---|---|---|---|---|---|---|
Liu et al. 2017 | China | Prostate cancer | 70 | Tissue | IHC | Negative | abcam | 8 |
Li et al. 2020 | China | Ovarian cancer | 100 | Tissue | IHC | Negative | NA | 7 |
Lu et al. 2012 | China | Renal cancer | 35 | Tissue | IHC | Total score ≤ 2 | Abcam (ab81163) | 8 |
Liu et al. 2009 | USA | Multiple cancers | 1020 | Tissue | TMA | Negative | NA | 7 |
Kim et al. 2012 | Korea | Multiple cancers | 360 | Tissue | IHC | ˂ 19% of the cells showed | GeneTex (GTX106942) | 8 |
Zeng et al. 2014 | China | Gastric cancer | 202 | Tissue | IHC | Total score ≤ 6 | Protein-Tech (16750-1AP) | 8 |
Huang et al. 2015 | China | Liver cancer | 144 | Tissue | IHC | Total score ≤ 3 | Santa Cruz (sc‑66649) | 8 |
Li et al. 2019 | China | Ovarian cancer | 85 | Tissue | IHC | Total score ≤ 6 | Protein-Tech (16750-1AP) | 8 |
Li et al. 2017 | China | Lung cancer | 180 | Tissue | IHC | Total score ≤ 2 | Santa Cruz (sc‑66649) | 8 |
Ding et al. 2015 | China | Gliomas | 98 | Tissue | IHC | Total score ≤ 2 | Santa Cruz (sc‑66649) | 8 |
Xu et al. 2017 | China | Gastric cancer | 60 | Tissue | IHC | NA | NA | 7 |
Xu et al. 2015 | China | Colorectal cancer | 126 | Tissue | IHC | Total score ≤ 4 | Santa Cruz (sc‑66649) | 8 |
Ji et al. 2018 | China | Liver cancer | 44 | Tissue | IHC | NA | Millipore (MABC565) | 7 |
Zhao et al. 2016 | China | Renal cancer | 58 | Tissue | IHC | Total score ≤ 2 | Santa Cruz | 8 |