Fig. 5
LLC tumor-induced cancer cachexia cause weight loss and skeletal muscle weakness. A The body weight growth curves of C57BL/6 mice in 22 days after LLC cells and PBS injection. B LLC tumor-bearing mice suffer from cancer cachexia. Weight changes of the tumor-free body, gastrocnemius and tibial anterior muscle between CN and TB group. Data (n = 8) were analyzed by t-test, **P < 0.01, ***P < 0.001, ****P < 0.0001. C LLC tumor-bearing mice suffer from muscle wasting. Representative images of H&E stained middle cross-section of the gastrocnemius from CN and TB mice. Data (n = 8) were analyzed by χ2 analysis, ****P < 0.0001