Fig. 7From: Characterization of a novel glucocorticoid-resistant human B-cell acute lymphoblastic leukemia cell line, with AMPK, mTOR and fatty acid synthesis pathway inhibitionTumorigenicity of NALM-6/HDR cells. a The growth curve of subcutaneous tumors in nude mice. All animal procedures were carried out in accordance with the guidelines established by the internal Institutional Animal Care and Use Committee and Ethics Committee guidelines of Sichuan University. b HE staining of the tumors derived from NALM-6 and NALM-6/HDR showed that the xenografts were composed of leukemia cells and blood vessels. Original magnification: × 400 magnification. (c-f) On IHC staining, both xenografts expressed GR, Glut-1, HKII, and 4E-BP1 proteins, with a relative lower expression of GR and HKII in NALM-6/HDR than that in NALM-6Back to article page