Fig. 5

Circ_0016760 regulated NSCLC cell processes and angiogenic ability under hypoxia via sponging miR-29b. A MiR-29b expression was detected by qRT-PCR in A549 and H1299 cells transfected with in-miR-29b or in-miR-con. B The impacts between circ_0016760 knockdown and miR-29b inhibitor on miR-29b expression under hypoxia were demonstrated by qRT-PCR in A549 and H1299 cells. C, D Transwell assay was employed to unveil the effects between circ_0016760 silencing and miR-29b inhibitor on the migration and invasion of A549 and H1299 cells under hypoxia. E, F Cell colony formation and MTT assays were performed to reveal the impacts between circ_0016760 repression and miR-29b inhibitor on the proliferation of A549 and H1299 cells under hypoxia. G Western blot assay was employed to unveil the effects between circ_0016760 silencing and miR-29b inhibitor on PCNA expression under hypoxia. H Tube formation assay was employed to unveil the effects between circ_0016760 silencing and miR-29b inhibitor on the tube formation of A549 and H1299 cells under hypoxia. *P < 0.05