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Fig. 5 | Cancer Cell International

Fig. 5

From: The circular RNA circSLC7A11 functions as a mir-330-3p sponge to accelerate hepatocellular carcinoma progression by regulating cyclin-dependent kinase 1 expression

Fig. 5

MiR-330-3p suppressed HCC cell proliferation and migration in vitro by targeting cyclin-dependent kinase 1 (CDK1). a Schematic illustration of target genes of miR-330-3p predicted by the Starbase, miRDB, Targetscan, and TCGA databases. b Relative mRNA and protein levels of CDK1 in HCCLM3 and Hep3B cells transfected with an miR-330-3p mimic or inhibitor. c Transfection efficiency was detected by qRT-PCR in HCCLM3 and Hep3B cells. d–f CCK-8, colony formation, and EdU assays detected the proliferation of HCCLM3 cells transfected with a mimic or mimic negative control, and Hep3B cells transfected with inhibitor or inhibitor negative control. Scale bar, 100 μm. g Cell migration detected by wound-healing assay in HCCLM3 cells transfected with a mimic or negative control mimic, and Hep3B cells transfected with inhibitor or inhibitor negative control. Scale bar, 200 μm. Data are means ± SD (*p < 0.05; **p < 0.01; ***p < 0.001)

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Cancer Cell International

ISSN: 1475-2867

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