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Fig. 1 | Cancer Cell International

Fig. 1

From: Prodigiosin inhibits cholangiocarcinoma cell proliferation and induces apoptosis via suppressing SNAREs-dependent autophagy

Fig. 1

PG promotes apoptosis by inhibiting the cellular activity of HuCCT-1 and TFK-1. A Structure of PG. B HuCCT-1, TFK-1, HUH28, QBC939, RBE, and CCLP-1 cells were incubated with different concentrations of PG (150–1200 nM) for 24 h, followed by CCK-8 to determine cell viability. 0 nM PG is the DMSO vehicle. C Different concentrations of PG inhibited the colony-forming ability of HuCCT-1 and TFK-1 cells. D EdU analysis showed that PG inhibited the proliferation of HuCCT-1 and TFK-1 cells with increasing concentration compared to the DMSO control group. E Apoptosis of HuCCT-1 and TFK-1 cells by flow cytometry; F Expression levels of Bcl-2 and Bax were analyzed by western blot assay; *P<0.05

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Cancer Cell International

ISSN: 1475-2867

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