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Fig. 5 | Cancer Cell International

Fig. 5

From: Identification and validation of cellular senescence patterns to predict clinical outcomes and immunotherapeutic responses in lung adenocarcinoma

Fig. 5

Characteristics of tumor mutations and biological pathways between CSS-high and CSS-low subgroups. A Comparison of differential mutated genes between CSS-low and CSS-high subgroups. B Interaction effect of differential mutated genes in patients in CSS-low and CSS-high subgroups. C GSEA analysis showed that the EMT pathway was activated in CSS-high subgroup in LUAD. DE EMT score (D) and differences in EMT hub genes including SNAI1, SNAI2, TWIST1, ZEB1, ZEB2, FN1 and VIM (E) between CSS-high and CSS-low subgroups. F Correlations between CCS and the known gene signatures in LUAD patients. Positive and negative correlation were marked with orange and blue, respectively; ns not significant; *P < 0.05; **P < 0.01; ***P < 0.001

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