Table 2 The functions of m6A demethylases in OC
From: Emerging role of m6A methylation modification in ovarian cancer
Eraser | Expression | Function | Mechanism | Model | Ref. |
|---|---|---|---|---|---|
ALKBH5 | Up | Promotion | ALKBH5-HOXA10 loop-mediates ALKBH5 expression, leading to JAK2 m6A demethylation and stabilization, thus OC resistance to cisplatin | In vitro; in vivo | [39] |
ALKBH5 | Up | Promotion | In OC cells co-cultured with M2 macrophages, TLR4-NF-κB-mediated ALKBH5 upregulation causes NANOG mRNA demethylation and stabilization | In vitro; in vivo | [79] |
ALKBH5/FTO | Down | Inhibition | ALKBH5 and FTO downregulation elevates m6A-mediated stability of FZD10 mRNA and causes PARPis resistance by activating Wnt/β-catenin signalling in BRCA-mutated OC cells | In vitro | [78] |
FTO | Down | Inhibition | FTO suppression increases m6A methylation to stabilize PDE1C and PDE4B mRNA, thus hindering CSC-related cAMP signalling | In vitro; in vivo | [77] |
FTO | Unknown | Unknown | circRAB11FIP1 promotes autophagy through FTO-mediated demethylation of ATG5 and ATG7 | In vitro | [95] |