Fig. 1
Analysis of the correlation of eIF4A1 expression and clinical characteristics of patients. a eIF4A1 expression was upregulated in various cancer types including pancreatic adenocarcinoma; b eIF4A1 was one of the top-upregulated genes of the protein synthesis-related eIF family in PDAC compared to healthy pancreatic tissues; c eIF4A1 was significantly overexpressed in PDAC tissues, log2[FC] = 1.162, P = 2.22e−16; d Immunofluorescence image of eIF4A1 localization (green) in pancreatic cancer cells (AsPC-1, Capan-2). eIF4A1 was predominantly located in the cytoplasm; e Representative images of IHC staining for eIF4A1 in a microarray comprising tumor and adjacent nontumor tissues, Scale bars: 100 μm. f Analysis of overall survival was compared according to the expression levels of eIF4A1 in PDAC tissues. Patients with high eIF4A1 expression had shorter overall survival (6 months vs. 9 months, log-rank test, HR = 2.096, 95% CI: 1.438–5.242, P = 0.0061)