Fig. 6

CircSEC24A promotes TGFBR2 expression via sponging to miR-606 and activates AKT signaling. A Go enrichment analysis was performed to explore the potential function on cellular component (CC), molecular function (MF) and biological process (BP), respectively. B KEGG enrichment analysis was performed to explore the potential signaling pathway correlated with CircSEC24A. C Western blot was performed to confirm the result of KEGG enrichment (PI3K/AKT signaling pathway). D Western blot was performed to further evaluate the key protein expression levels of AKT signaling pathway. Then miR-606 inhibitor or TGFBR2 vector was respectively cultured with si-circSEC24A pancreatic cancer cells. The signaling pathway markers was measured by western blot