Table 3 Comparison of the effects of different types of NK cell immunotherapies for targeting malignancies
From: NK cell upraise in the dark world of cancer stem cells
NK source | Advantages | Disadvantages |
|---|---|---|
Autologous NK cells | Universal Safe | Low efficacy |
Allogenic NK cells | Highly effective against some malignancies | no standard protocols or products |
CAR NK cells | Highly potentiate NK cell antitumor activity; more efficiency and safer than CAR T cells | Difficult manipulate Difficult expansion |
NK cell lines | Unlimited Homogeneous well-defined highly active population low cost | Low efficacy safety concerns need to be irradiated |