Fig. 6
From: miR-133a targets YES1 to reduce cisplatin resistance in ovarian cancer by regulating cell autophagy
YES1 overexpression induces cisplatin resistance by regulating autophagy in vivo. A Nude mice and ovarian tumour tissues from the YES1-NC and YES1-OE groups at Day 14 after cisplatin injection intraperitoneally. B Growth curves of tumours were determined based on tumour size, which was measured every 3 Days (n = 5), and it showed significant differences in tumour volume at Days 7, 11 and 14. C The miR-133a expression showed no difference between the YES1-NC and the YES1-OE groups. D and E The YES1 expression increased at both the mRNA (D) and protein levels (E) in the YES1-OE group compared with the YES1-NC group. F LC3B expression level of xenograft tumours in the YES1-NC group and YES1-OE group after cisplatin treatment. For comparisons, Student’s t test was performed; *p < 0.05, **p < 0.01, ***p < 0.001