Table 2 Subgroup Meta-analysis of FPR and OS
Subgroup | No. of cohorts | No. of patients | Pooled HR (95% CI) | P | Heterogeneity I2 (%) Ph | |
|---|---|---|---|---|---|---|
Altogether | 10 | 3313 | 1.88(1.53,2.32) |  < 0.001 | 50.8 | 0.032 |
Publishing time | ||||||
  < 2020 | 6 | 1872 | 2.10 (1.67,2.64) |  < 0.001 | 25.9 | 0.24 |
  ≥ 2020 | 4 | 1441 | 1.61 (1.25,2.09) |  < 0.001 | 53.0 | 0.095 |
Sample capacity | ||||||
  < 330 | 5 | 1012 | 2.39 (1.55,3.70) |  < 0.001 | 60.9 | 0.037 |
  ≥ 330 | 5 | 2301 | 1.57 (1.35,1.83) |  < 0.001 | 14.3 | 0.323 |
Methods for choosing FPR cut-off value | ||||||
 ROC | 2 | 645 | 1.47(1.21,1.78) |  < 0.001 | 0.0 | 0.635 |
 X-tile | 8 | 2668 | 2.11(1.61,2.77) |  < 0.001 | 50.8 | 0.047 |
Cut-off value | ||||||
  < 18 | 4 | 1235 | 1.96 (1.34,2.89) | 0.001 | 69.8 | 0.019 |
  ≥ 18 | 6 | 2078 | 1.75(1.44,2.12) |  < 0.001 | 39.0 | 0.146 |
Study designed type | ||||||
 Retrospective | 4 | 1536 | 1.50 (1.28,1.76) |  < 0.001 | 2.3 | 0.381 |
 Prospective | 6 | 1777 | 2.32 (1.68,3.19) |  < 0.001 | 43.6 | 0.115 |
Treatment option | ||||||
 Surgical resection | 7 | 2586 | 1.92 (1.48,2.48) |  < 0.001 | 62.8 | 0.013 |
  Others | 3 | 727 | 1.80 (1.29,2.52) | 0.001 | 3.0 | 0.357 |
Cancer site | ||||||
 GC | 2 | 633 | 1.83(1.33,2.51) |  < 0.001 | 20.8 | 0.261 |
 CRC | 5 | 1858 | 2.00(1.42,2.81) |  < 0.001 | 49.5 | 0.095 |
 GBC | 1 | 220 | 1.57(1.00,2.46) | 0.049 | NA | NA |
 HCC | 1 | 230 | 4.16(2.06,8.39) |  < 0.001 | NA | NA |
 ESCC | 1 | 372 | 1.43(1.15,1.78) | 0.002 | NA | NA |