Fig. 6From: miR-199b-3p contributes to acquired resistance to cetuximab in colorectal cancer by targeting CRIM1 via Wnt/β-catenin signalingAntagomiR-199b-3p enhances the efficacy of CTx on CRC-CTxR tumor growth in vivo. After cell inoculation for a week, the volume of xenograft tumors in each group was recorded every five days (days 7, 12, 17, 22, 27, 32, and 37), A Growth curve and B representative images of xenograft tumors from each group. Tumor weights and D volume were recorded at the end of the experiments. E IHC staining determined the protein expression of Ki-67 and MACC1 in xenograft tumors (Scale bars: 100 μm). *P < 0.05 and ***P < 0.005 compared with saline group; ###P < 0.005 compared with CTx groupBack to article page