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Fig. 2 | Cancer Cell International

Fig. 2

From: Golgi phosphoprotein 3 promotes angiogenesis and sorafenib resistance in hepatocellular carcinoma via upregulating exosomal miR-494-3p

Fig. 2

GOLPH3 enhances angiogenesis through exosomes in HUVEC model. a Representative images of exosomes obtained by transmission electron microscopy (TEM). b Size distribution of exosomes analyzed by NanoSight. c Expression levels of exosome markers: CD63 and Alix as determined by western blot analysis. d, e Tube formation assay of HUVECs treated with exosomes derived from GOLPH3-downregulated HCC cells compared with vector cells. (f and g) Capillary tube formation assay of HUVECs treated with exosomes derived from GOLPH3-overexpression HCC cells compared with control cells. h, i Migration rate of HUVECs treated with exosomes as determined by transwell migration assay. j, k Migration rate of HUVECs treated with exosomes as determined by transwell migration assay. Data are expressed as mean  ±  SD of 3 independent experiments and analyzed by one-way ANOVA with Dunnett’s multiple comparisons test (d, e, h, i), or t test (f, g, j, k). ***p  < 0.001; Exo exosome

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Cancer Cell International

ISSN: 1475-2867

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