Fig. 5

Function network of LMNB1 and LMNB1-related genes in TCGA. A GEPIA2 was used to acquire the top 100 LMNB1-correlated genes across all TCGA cancers. TMPO, KIF11, NUSAP1, KIF15, MCM6 and PLK4 were the most six correlated genes with LMNB1. B STRING network was used to obtain the top 50 genes of which the corresponding proteins have been experimentally determined lamin B1-binding. C The venn diagram visualized the intersection of LMNB1-correlated genes and lamin B1-binding proteins. D KEGG pathway analysis was conducted using LMNB1-correlated genes and lamin B1-binding proteins. E Biological process GO term enrichment analysis based on LMNB1-related partners was also performed. F Genes involved in the most enriched process were plotted