Fig. 6

Correlation between LMNB1 expression and DNA homologous recombination repair. A The correlation of mRNA expression between LMNB1 gene and PROfound signature across all types of cancer in TCGA was calculated by GEPIA2. The overview was presented in a heatmap while cancers with Pearson correlation coefficient equal to or greater than 0.80 were highlighted with solid line borders and showed in detail. B The correlation of mRNA expression between LMNB1 and every single gene of PROfound signature in TCGA datasets was analyzed and visualized by TIMER2.0. C The correlation of mRNA expression between LMNB1 gene and PROfound signature in PRAD was investigated with GEPIA2. D Relative expression of HRR genes was determined by qRT-PCR in LMNB1-overexpressing and control cells. E Representative pictures of lamin B1 and BRCA1 IHC staining in PRAD specimens (n = 81). Scale bars represent 100 μm. F The correlation between lamin B1 and BRCA IHC scores in PRAD was evaluated by Spearman correlation analysis. G The correlation between LMNB1 and BRCA mRNA expression in prostate cells was examined with Pearson correlation analysis