Table 1 Clinical characteristics of patients by PD-L1 expression groups
|  | Negative group (TPS < 1%) | Intermediate group (TPS 1%-49%) | High group (TPS ≥ 50%) | P value |
|---|---|---|---|---|
N = 248 | 124 (50%) | 93 (38%) | 31 (12%) |  |
Gender | Â | Â | Â | Â |
Male (n = 134) | 65 (52%) | 49 (53%) | 19 (61%) | 0.66 |
Female (n = 117) | 59 (48%) | 44 (47%) | 12 (39%) |  |
Age (years) | Â | Â | Â | Â |
Median (range) | 58 (23 ~ 84) | 58 (27 ~ 80) | 60 (32 ~ 73) | 0.86 |
TMB (Mut/Mb) | Â | Â | Â | Â |
Median (IQR) | 4.0 (2.01 ~ 5.36) | 3.4 (2.68 ~ 6.70) | 6.0 (4.02 ~ 14.41) |  < 0.001* |
TNB (Neo/Mb) | Â | Â | Â | Â |
Median (IQR) | 1.3 (0.67 ~ 2.68) | 1.3 (0.67 ~ 3.35) | 2.7 (1.34 ~ 4.02) | 0.09 |
HLA LOH | Â | Â | Â | Â |
Negative | 98 (79%) | 77 (83%) | 21 (68%) | 0.16 |
Positive | 26 (21%) | 16 (17%) | 10 (32%) | Â |