Fig. 5

LINC01128 silencing suppressed tumor growth in pancreatic cancer cells and LDHA protein in vitro. a Schematic diagram of miR-561-5p, wild-type LDHA, and LDHA mutant. b The luciferase reporter assay showed luciferase vitality in the combination of miR-561-5p mimic/control and LDHA wild-type/mutant. c QRT-PCR and western blotting were performed to detect LDHA expression of LINC01128 silencing and co-transfecting LINC01128 shRNA and miR-561-5p at the transcription and translation levels. d, e CCK-8 assays and transwell assays were used to detect cell proliferation, migration, and invasion of BxPC-3 cells transfected with miR-561-5p inhibitor and co-transfected with miR-561-5p inhibitor and LDHA shRNA. Data are presented as mean ± SD of three independent experiments. *p < 0.05, **p < 0.01