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Fig. 6 | Cancer Cell International

Fig. 6

From: SGLT2 inhibition restrains thyroid cancer growth via G1/S phase transition arrest and apoptosis mediated by DNA damage response signaling pathways

Fig. 6

SGLT2 was increased and positively related to cyclin D3 in thyroid cancer patients. A SGLT2 levels were increased in thyroid cancer comparing with adjacent tissue in TCGA dataset. B Receiver operating characteristic curve for SGLT2 as a diagnostic criterion for thyroid cancer. C SGLT2 levels were increased in thyroid cancer comparing with paired adjacent tissue in GEO dataset. D SGLT2 levels were increased in thyroid cancer comparing with benign thyroid nodules. E SGLT2 protein level was increased in thyroid cancer as comparing with adjacent tissue detected by IHC. Representative images of SGLT2 IHC staining in thyroid cancer and its adjacent tissue (Left panel). Paired t-TEST was used for comparison. F The levels of cyclin D3 were increased in thyroid cancer tissue in GEO and TCGA dataset. G The levels of SGLT2 were positively related with cyclin D3 in GEO and TCGA dataset. A t-TEST was used to determine statistical significances

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Cancer Cell International

ISSN: 1475-2867

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